
Irina Novikova, Head of Chair of clinical laboratory diagnostics, allergology and immunology, Gomel State Medical University, Doctor of Medical Sciences, professor.
Summary The article describes the characteristics of primary immunodeficiency clinical manifestations and modern approaches to their detection. Screening tests and tests for detailed examination depending on the supposed defect in the immune system are described.
Key words: primary immunodeficiency, laboratory diagnostics.
References
1. Immunodefitsitnye sostoyaniya / Ed.by V.S.Smirnov. St.Petersburg, 2000. In Russian
2. J.M. Garcia et al. / J.Invest. Allergol. Clin. Immunol. 2010. Vol. 20(3). P. 185–194.
3. Notarangelo L.D. et al. Primary immunode?ciencies: 2009 update // J Allergy Clin Immunol. 2009. No 124. Р. 1161–1178.
4. Sewell W.A.C., Khan S., Dore P.C. Early indicators of immunodeficiency in adults and children: protocols for screening for primary immunological defects // Clinical and Experimental Immunology. 2006, №145. P. 201–203.
5. Verbsky J.W. Grossman W.J. Gellular and Genetic Basis of Primary Immune Deficiencies // Pediatr Clin. 2006. No Am 53. P. 649–684.
6. Vale A.M., Schroeder H.W. Clinical consequences of defects in B-cell development // J Allergy Clin Immunol. 2010. No 125. Р. 778–787.
7. Chan K., Puck J.M. Development of population-based newborn screening for severe combined immunodeficiency // J Allergy Clin Immunol. 2005. No 2.
